| 1. Identificação | ||||
| Tipo de Referência | Artigo em Evento (Conference Proceedings) | |||
| Site | mtc-m21c.sid.inpe.br | |||
| Código do Detentor | isadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S | |||
| Identificador | 8JMKD3MGP3W34R/43L8U5S | |||
| Repositório | sid.inpe.br/mtc-m21c/2020/11.23.10.43 | |||
| Repositório de Metadados | sid.inpe.br/mtc-m21c/2020/11.23.10.43.53 | |||
| Última Atualização dos Metadados | 2022:01.04.01.35.38 (UTC) administrator | |||
| Chave Secundária | INPE--PRE/ | |||
| Chave de Citação | WacheskHuCoTaVaCoTr:2020:SyChDi | |||
| Título | Synthesis and characterization of diamond nanoparticles with methylene blue for cancer photodynamic therapy  | |||
| Ano | 2020 | |||
| Data de Acesso | 13 maio 2024 | |||
| Tipo Secundário | PRE CN | |||
| 2. Contextualização | ||||
| Autor | 1 Wachesk, Cristiane da Costa 2 Hurtado, Carolina Ramos 3 Correia, Rebeca Falcão Borja de Oliveira 4 Tada, Dayane Batista 5 Vasconcelos, Getúlio 6 Corat, Evaldo José 7 Trava-Airoldi, Vladimir Jesus | |||
| Identificador de Curriculo | 1 2 3 4 5 6 8JMKD3MGP5W/3C9JH33 | |||
| Grupo | 1 2 3 4 5 6 LABAS-COCTE-INPE-MCTIC-GOV-BR 7 LABAS-COCTE-INPE-MCTIC-GOV-BR | |||
| Afiliação | 1 Universidade Federal de São Paulo (UNIFESP) 2 Universidade Federal de São Paulo (UNIFESP) 3 Universidade Federal de São Paulo (UNIFESP) 4 Universidade Federal de São Paulo (UNIFESP) 5 Instituto de Estudos Avançados (IEAv) 6 Instituto Nacional de Pesquisas Espaciais (INPE) 7 Instituto Nacional de Pesquisas Espaciais (INPE) | |||
| Endereço de e-Mail do Autor | 1 2 3 4 5 6 evaldo.corat@inpe.br 7 vladimir.airoldi@inpe.br | |||
| Nome do Evento | Encontro de Outono Sociedade Brasileira de Física | |||
| Localização do Evento | Online | |||
| Data | 23 a 26 nov. | |||
| Histórico (UTC) | 2020-11-23 10:43:53 :: simone -> administrator :: 2022-01-04 01:35:38 :: administrator -> simone :: 2020 | |||
| 3. Conteúdo e estrutura | ||||
| É a matriz ou uma cópia? | é a matriz | |||
| Estágio do Conteúdo | concluido | |||
| Transferível | 1 | |||
| Tipo do Conteúdo | External Contribution | |||
| Palavras-Chave | HFCVD diamond PDT CVD Diamond Nanoparticles (CVD-DNPs) Drug Delivery Melanoma | |||
| Resumo | Diamond nanoparticles (DNPs) have showed in vitro and in vivo biomedical applicability due to their low toxicity and biocompatibility. Recent studies have focused on the potential use of (DNPs) as suitable vehicles for improving drug delivery in cancer treatment. The advantages of DNPs lies in their high stability and small size compared to other carbon-based nanomaterials. In this work, CVD-diamond nanoparticles (CVD-DNPs) were synthesized and evaluated regarding their application as a new drug delivery platform for metastatic melanoma therapy. A new synthesis technique developed DNPs from CVD diamond thin film. This type of diamond has the same physical and chemical properties as a natural diamond: extreme hardness, excellent thermal conductivity, low coefficient of friction, biocompatibility, chemically inert for temperatures below 8000 C, among others. The main objective of this study was to produce CVD-DNPs by laser ablation and to evaluate their cytotoxicity. A pulsed, ytterbium-doped fiber (Yb) was used to form DNPs in the pure aqueous medium (Milli-Q). The characterization by FT-IR, X-Ray, DLS, RAMAN, SEM, and TEM demonstrated the successful synthesis of CVD-DNPs with a hydrodynamic diameter of 57 and 54 nm. In vitro studies performed for 24h and 48h resulted in viability of 70-80% of cells incubated with CVD-DNPs at 250 μg/mL, which demonstrated a insignificant cytotoxic effect. The irradiation was performed with laser light with λ = 665nm (0,3J/cm2), for 1 min. Quantification of cell viability was performed by the colorimetric method, and performed a reading in a microplate reader at 540nm. Determination of Methylene Blue was AM (1,88 μg / mL), (2,82 μg / mL), (5,64 μg / mL) respectively, in the presence and absence of light. Using the protocol of PDT observed that there is one of the cytotoxic effects of AM with statistical significance. The results showed that both platforms promoted the solubility of (MB / water) and (MB / CVD-DNPs) which is essential in biological applications. MB conjugated with CVD-DNPs proved to be an adequate platform for the application of PDT. Thus, these results suggest a potential use of CVD-DNPs as a drug delivery platform for antitumoral therapy. | |||
| Área | FISMAT | |||
| Arranjo | urlib.net > BDMCI > Fonds > Produção anterior à 2021 > LABAS > Synthesis and characterization... | |||
| Conteúdo da Pasta doc | não têm arquivos | |||
| Conteúdo da Pasta source | não têm arquivos | |||
| Conteúdo da Pasta agreement |
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| 4. Condições de acesso e uso | ||||
| Grupo de Usuários | simone | |||
| Visibilidade | shown | |||
| Permissão de Atualização | não transferida | |||
| 5. Fontes relacionadas | ||||
| Unidades Imediatamente Superiores | 8JMKD3MGPCW/3ESR3H2 | |||
| Acervo Hospedeiro | urlib.net/www/2017/11.22.19.04 | |||
| 6. Notas | ||||
| Campos Vazios | archivingpolicy archivist booktitle callnumber copyholder copyright creatorhistory descriptionlevel dissemination doi e-mailaddress edition editor format isbn issn label language lineage mark mirrorrepository nextedition notes numberoffiles numberofvolumes orcid organization pages parameterlist parentrepositories previousedition previouslowerunit progress project publisher publisheraddress readergroup readpermission rightsholder schedulinginformation secondarydate secondarymark serieseditor session shorttitle size sponsor subject targetfile tertiarymark tertiarytype type url versiontype volume | |||
| 7. Controle da descrição | ||||
| e-Mail (login) | simone | |||
| atualizar | ||||